The Journey of Magie Francis

Reflecting on her journey, Magie Francis shared profound insights: "I wish I had known that it’s OK not to have all the answers right away. The whole point is to keep learning and growing." Previously studying flu viruses and vaccines under the mentorship of virologist Dr. Alyson Kelvin, Francis pivoted to COVID-19 research as the virus emerged. Her investigation delved into how previously encountered respiratory viruses, such as those that cause the common cold, might influence vulnerability to SARS-CoV-2 and its evolving variants.

When SARS-CoV-2 emerged, we needed to understand who it could infect and how our bodies would respond, Francis remarked, emphasizing the growing complexity of viral mutations and the immune responses they trigger. Her studies highlighted that age, sex, and prior viral exposures significantly impact COVID-19 outcomes, providing critical data for ongoing public health efforts.

Moreover, her research indicated that while exposure to common cold coronaviruses might not confer strong protection against COVID-19, ongoing vaccination and safety precautions remain vital.

Juveriya Qamar Khan's Innovative Approach

Khan, who earned her master's degree in virology in India before moving to Canada, similarly transformed her PhD focus from Bovine Viral Diarrhea Virus to SARS-CoV-2. The existing experience with RNA viruses made the transition seamless for her, allowing Khan to delve into how the virus interacts with human host factors to replicate.

Her groundbreaking work also explored the development of drug therapies targeting specific molecules crucial for the virus, signaling hope for repurposing established medications initially designed for other diseases. "We aimed to identify which existing drugs could be effective against SARS-CoV-2. Some were already proven safe for human use, making them prime candidates for rapid exploration," Khan explained.

Looking Ahead: The Future of Research

Both researchers underscored the importance of camaraderie and a robust support system during their arduous PhD journeys, especially during such turbulent global events. Khan referred to her lab as her second home, filled with colleagues that provided both scientific discourse and emotional support.

As they prepare for new chapters, Khan is engaging in post-doctoral studies, expanding her research under Dr. Anil Kumar, while Francis remains involved in ongoing research projects back in Atlantic Canada. Both graduates express excitement for future opportunities — a testament to their resilience and dedication.

"Graduate school is challenging, but if you love what you're doing and are prepared to work hard (and have some fun), a PhD might be the right path for you," advised Francis, reminding future scholars of the importance of prioritizing their well-being amidst the rigors of academia.

In a time when the scientific community is under immense pressure, Francis and Khan's contributions not only forward our understanding of COVID-19 but also stand as a beacon of hope and determination in the face of adversity. Their journeys emphasize the power of adaptability and passion in the relentless pursuit of knowledge.