Breakthrough Study Targets Dementia Risks in Underrepresented Seniors

In a groundbreaking study, researchers from the Indiana University School of Medicine, Eskenazi Health, and Regenstrief Institute have proven it’s possible to engage older adults with limited formal education in dementia prevention trials. This demographic faces a significantly heightened risk for Alzheimer's and related dementias.

The MINDSpeed Trial: A Unique Approach

The MINDSpeed trial, a randomized study involving 180 older participants from Marion County, Indiana, sought to evaluate whether a diet enriched with polyphenols—plant-derived compounds found in nutritious foods like nuts and berries—combined with online cognitive training could enhance brain function in adults with 12 years or fewer of education.

How the Trial Worked

Participants were randomly assigned to one of four groups for a three-month active intervention, receiving either: - Polyphenol-rich snacks and cognitive training - Polyphenol-rich snacks combined with control games - Control snacks with cognitive training - Control snacks along with control games With home-delivered snacks and online gaming via tablets provided by the researchers, cognitive assessments were conducted at three and six months.

Encouraging Outcomes and Implications

Across all groups, there were modest improvements in cognitive function, with effect sizes ranging from 0.15 to 0.35. While no single method proved superior, the study highlights that older adults with limited education, often overlooked in dementia research, can effectively participate in and benefit from preventative measures.

The Research Team's Insights

According to lead author Dr. Daniel O. Clark, this demographic not only faces higher dementia risks but has often been excluded from research efforts. "This study confirms we can successfully involve these adults in trials and witness cognitive improvements," he stated.

Co-author Dr. Briana Sprague noted, "Participants showed remarkable engagement in the trial, illustrating that with the right support, cognitive training and brain-healthy snacks can be feasibly delivered to underserved older adults. Ultimately, this could reshape dementia prevention strategies."

Future Directions for Research

The study indicates that more extensive interventions may be required to observe stronger cognitive effects and suggests that ongoing follow-up is essential. There is a pressing need to develop tailored dementia prevention strategies for older adults with limited education to ensure they receive the support they deserve.