A Wake-Up Call for HIV Research

A groundbreaking analysis from the PREPARE trial reveals a concerning trend: 52% of middle-aged adults living with HIV experience notable declines in physical function over time. Published in the June 2025 issue of *Open Forum Infectious Diseases*, this study stresses the urgent need to identify those at risk to improve the quality of life for aging individuals with HIV.

Study Insights: Who is Affected?

The study examined 569 HIV-positive participants, with a median age of 51. Curious gender dynamics emerged, with 81% identifying as male and 52% as White. Researchers measured physical function annually through various tests, including gait speed and grip strength, highlighting that while the overall declines were modest, the variability among individuals was significant.

Risk Factors You Need to Know!

Key demographic and clinical risk factors emerged for physical function decline, including being female, non-White, and older. In-depth analysis also revealed other frightening predictors: a history of depression treatment, high body mass index (BMI), and elevated inflammation markers, such as high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6).

Antiretroviral Therapy: A Double-Edged Sword?

The link between antiretroviral therapy (ART) and physical function is critical. Older therapies like AZT and Efavirenz have been associated with muscle and nerve issues, potentially accelerating the decline in physical function, especially among those experiencing weight gain. This raises an important question: Can treatment simultaneously help while causing physical setbacks?

Infectious Disease Specialists: Key Players in Intervention!

Infectious disease specialists play a central role in recognizing early signs of functional decline among their patients. They have the unique opportunity to provide preventive strategies and manage drug interactions that could exacerbate physical impairment. Early intervention could be the key to maintaining mobility and overall wellness in aging HIV patients.

What This Means for the Future of HIV Care

Routine screening measures—like chair rise tests or gait speed assessments—are essential for early detection of physical decline. These findings underscore an alarming reality: as more individuals with HIV age, proactive care plans must incorporate not only medical management of the virus but also strategies to enhance physical function. Ignoring this issue could have devastating effects on the quality of life for an entire generation.

Conclusion: The Need for Awareness and Action!

With 52% of middle-aged adults with HIV experiencing physical function decline, the stakes have never been higher for healthcare providers. As research continues to unfold, the community must act swiftly to address these challenges head-on. Ensuring that individuals with HIV lead active, fulfilling lives as they age is not just a goal; it’s a necessity.