As we transition into fall, the looming threat of respiratory viruses such as the flu, RSV, and COVID-19 is becoming increasingly apparent. The colder weather and packed indoor spaces can lead to a rise in infections, but thankfully, vaccines are here to bolster our defenses. This season, in addition to flu shots and RSV vaccines, there are updated COVID-19 vaccines from Pfizer-BioNTech, Moderna, and Novavax available to reduce the risk of hospitalization.

This year, adults have a pivotal decision to make regarding their COVID vaccination: choose the cutting-edge mRNA vaccines from Moderna or Pfizer or opt for the Novavax vaccine, a protein-based alternative that utilizes more traditional methodologies. All three vaccines have received authorization from the US Food and Drug Administration (FDA). While mRNA vaccines have dominated since their introduction, Novavax is gradually gaining traction among those looking for alternatives.

The Novavax vaccine is particularly suited for individuals who are hesitant about mRNA vaccines or those who wish to explore the 'mix-and-match' strategy for bolstering their immune response. Dr. Amesh Adalja, an esteemed infectious disease expert at Johns Hopkins, emphasizes the necessity of diversifying our vaccine arsenal: "Although mRNA vaccines have taken the lead, different vaccine technologies play crucial roles in addressing various pathogens."

What Sets Novavax Apart from Pfizer and Moderna?

Unlike the mRNA vaccines, which deliver genetic instructions to provoke an immune response, Novavax adopts a traditional approach by using a protein-based formula. It incorporates genetically engineered insect viruses that display COVID spike proteins, which are vital for the virus's ability to infect cells. Notably, Novavax is paired with an immune response booster known as an adjuvant to enhance its effectiveness.

Differences also exist in the strains the vaccines target. The mRNA vaccines have been updated to focus on the KP.2 strain of COVID-19, while Novavax primarily targets the earlier JN.1 strain, considered the parent of KP.2. While the FDA considers KP.2 vaccines as preferred, it's anticipated that all vaccines will offer protection against severe illness and death.

Financial Considerations for the Vaccines

As of now, no COVID vaccines will be available for free under a government program, leaving most individuals reliant on insurance to cover costs. Unfortunately, for those without insurance, out-of-pocket expenses may be necessary. GoodRx indicates that Novavax's retail price hovers around $191, and they are offering coupons to help mitigate this cost.

Who Should Consider Novavax?

Approved for adults and children ages 12 and older, Novavax presents a viable option for those who prefer not to take the mRNA vaccines. It also appeals to individuals seeking that mix-and-match strategy to enhance their immunity. Early research hints that Novavax might yield fewer short-term side effects like muscle fatigue and nausea, but conclusive evidence on this is lacking. As pharmacist Joshua Murdock notes, individual responses can vary significantly, and the CDC currently does not favor one vaccine type over another.

Both mRNA vaccines have been observed to elicit more pronounced side effects compared to others, with some individuals reporting flu-like symptoms such as headaches and fatigue post-vaccination. As with any vaccine, experiencing mild symptoms can indicate that the immune system is responding effectively.

It's essential to note that rare cases of myocarditis have been associated with COVID vaccinations, particularly in younger populations. Newer data are necessary to ascertain how different vaccines, including Novavax, will hold up in the ongoing fight against COVID, especially given the increased cases seen throughout the summer.

As we gear up for what could be a tumultuous fall and winter, understanding the various COVID vaccine options available is crucial. Dr. Adalja points out that while current evidence does not strongly favor one vaccine over another for specific individuals, ongoing research into personalized vaccine recommendations is on the horizon.

Where to Get Your Novavax Vaccine

Starting September 13, individuals can find Novavax vaccines at various pharmacy chains, including: - CVS - Rite Aid - Walgreens - Costco - Publix - Sam's Club - Kroger - Meijer - Other independent pharmacies or grocers

To ensure a healthier fall season, considering all available vaccination options, including Novavax, is essential for personal and public health.