In an enlightening interview featured in Brain Medicine, Dr. Raúl Andero Galí shines a spotlight on how his early enchantment with classical piano has influenced his pioneering work in the realm of neuroscience. As an ICREA Research Professor at the Autonomous University of Barcelona, Dr. Andero Galí embarks on ambitious research that intricately links the fear responses of mice and humans—a breakthrough that could redefine treatment methodologies for PTSD and anxiety disorders.

Dr. Andero Galí has dedicated his career to exploring the complex relationship between stress and memory. “All animals encounter threats throughout their lives, activating crucial stress responses that are essential for survival,” he elaborates. “Our memories, which are shaped by our experiences, are not rigid truths but plastic constructs influenced by our emotions—a concept that captivates my pursuit of knowledge.”

His cutting-edge laboratory employs advanced techniques such as in vivo calcium imaging in mice alongside human fear response assessments. Presently, his research delves into the compelling impact of the menstrual cycle on fear memory formation. Utilizing sophisticated methods to monitor sex hormones and fear responses across species, his findings could illuminate previously obscured physiological mechanisms.

What sets Dr. Andero Galí apart is his resolute dedication to dismantling antiquated research silos separating animal studies from human studies. “We must transform how neuroscience is conducted by integrating animal and human research,” he emphasizes. “By promoting cross-species studies, we unlock a more profound understanding of the human brain.”

His lab's focal point on neuropeptide receptors unveils exciting possibilities for drug development. Unlike conventional medications that affect the entire brain indiscriminately, targeting these receptors—primarily found in emotional sectors of the brain—holds the promise of delivering more tailored and effective treatments for fear-related disorders.

Dr. Andero Galí's transition from a musician to a neuroscientist illustrates the innovative thinking that drives scientific progress. His lab embodies this philosophy, fostering an environment that prioritizes intellectual development and collaboration. “Creating a healthy and positive lab culture is paramount; I want members to engage and learn from one another dynamically,” he asserts.

Recent publications, including a notable paper in Science Advances slated for release in 2024, exemplify the triumph of this integrated method. These studies reveal striking parallels between neuronal activity in mice and neuroimaging data in humans during fear responses, propelling important inquiries into the sex differences in fear processing and the potential for more precisely targeted therapies.

Dr. Andero Galí's unique journey, shaped by the rhythms of both music and neuroscience, positions him as a prominent figure in the quest to understand and treat fear-based disorders—inspiring a new wave of research that transcends traditional boundaries.