1. Master the Pin-Pull and Trap Blocking Scheme

Despite transitioning to a new defensive coordinator, the essence of the 49ers' defensive approach remains largely intact from previous seasons. Expect the Lions to replicate the pin-and-pull blocking strategy that proved successful in last year’s NFC Championship. Their capable offensive line, combined with agile running backs, stands ready to exploit gaps on the edges, particularly against the 49ers’ aggressive defensive front.

2. Put Jahmyr Gibbs in Space

With David Montgomery sidelined, the Lions will lean heavily on Jahmyr Gibbs. After a standout performance against the Bears with 154 total yards, Gibbs is poised to exploit the 49ers’ defensive weaknesses in zone coverage. When the 49ers go light in the box, expect innovative plays designed to unleash Gibbs’ speed and agility, potentially leading to significant offensive gains.

3. Utilize Jameson Williams to Attack the Secondary

Jameson Williams' speed can stretch the field against a 49ers squad that often employs single-high safety coverages. After a breakout performance with five catches for 143 yards last week, Williams is an integral component of the Lions’ aerial strategy. Utilizing him effectively will not only open opportunities for himself but also create space for running plays and shorter passes.

4. Make the Most of Short Passes

The Lions boast the NFL's top short-passing offense, which aligns perfectly with the 49ers' defensive strategy aimed at limiting big plays. With Amon-Ra St. Brown leading the charge—boasting an impressive 81.5% catch rate—the Lions should take advantage of these opportunities to maximize yards after the catch. Scoring on third down will be crucial, especially against a defense that has struggled to contain opponents in critical situations.

5. Emphasize Play-Action Passes

The Lions are among the league’s leaders in play-action usage, and quarterback Jared Goff excels with this strategy—recording a 73.7% completion rate when faking handoffs. The 49ers have shown vulnerability when facing play-action, presenting the Lions with an opportunity to set up big plays downfield that could shift momentum in their favor.

6. Excel in the Red Zone

The Lions have thrived in the red zone this season, converting 67.7% of their opportunities into touchdowns, while the 49ers’ defense has struggled in this area. For the Lions, capitalizing on this strength will be key; for the 49ers, tightening up their red zone defense is essential for limiting points.

7. Outperform in the Run Game

Injuries have plagued the 49ers’ rushing attack, leaving them vulnerable. The Lions need to execute their run defense with consistency and intensity, confronting whatever remains of the 49ers’ offensive line. If they can dominate in the trenches early on, it will set the tone for a successful defensive performance.

8. Take Advantage of Defensive Formations

Although the 49ers may struggle in the run game, stacking the box can yield dividends for the Lions. This strategy negates the 49ers' running efficiency, especially given the current state of their lineup. The Lions’ defensive line has shown strength when matched against a stacked box, making this approach sensible for containing any push from San Francisco.

9. Limit Quarterback Brock Purdy

Containing the pocket is essential in managing Brock Purdy’s effectiveness as a passer. The Lions need to keep constant pressure on him while ensuring that they maintain containment to prevent extended plays that could lead to big gains. Awareness and discipline in their defensive assignments will be imperative to execution.

10. Implement a Strategic Blitzing Plan

The Lions’ defense thrives on blitzing and must continue this trend against the 49ers. With Purdy’s offensive line undergoing significant changes, an aggressive blitz strategy could disrupt rhythm and create turnover opportunities. The Lions have proven adept at handling press coverage situations while blitzing, enhancing the chance of shutting down any quick offensive strikes from the 49ers.