Important Inactive Updates for 1 p.m. ET Games:

- **Keenan Allen, WR, Chicago Bears:** OUT due to a heel injury. This opens the door for Rome Odunze and DJ Moore to receive increased targets.

- **Travis Homer, RB, Chicago Bears:** OUT, heading to injured reserve with a finger injury. Khalil Herbert steps up as the primary backup to D'Andre Swift, while Roschon Johnson joins the mix, creating a potential running back committee.

- **David Njoku, TE, Cleveland Browns:** OUT with an ankle injury. Jordan Akins is expected to step in as the starter, but there may be limited offensive strategies involving tight ends for the Browns.

- **Joe Mixon, RB, Houston Texans:** OUT due to an ankle issue. Cam Akers takes the lead role, with Dare Ogunbowale getting opportunities on passing downs.

- **Jordan Love, QB, Green Bay Packers:** INACTIVE for the day. This suggests Malik Willis will get another chance as the starting quarterback for the Packers.

- **A.J. Brown, WR, Philadelphia Eagles:** OUT with a hamstring injury. This situation leaves DeVonta Smith as the top target, with potential surprise plays from Britain Covey.

Surprising Active Players:

- **Michael Pittman Jr., WR, Indianapolis Colts:** Active despite back issues that prevented him from practicing on Friday. His presence on the field could be crucial for the Colts’ passing game.

- **Justin Herbert, QB, Los Angeles Chargers:** Active and ready to kick off, though fans should keep an eye on potential substitutions, which could alter the game dynamics.

Inactives for Late Games (4 p.m. ET):

- **Cooper Kupp, WR, Los Angeles Rams:** OUT with an ankle injury. Kupp has been a key figure in the Rams’ offense and his absence will be felt. Expect Demarcus Robinson to rise as the primary receiving option.

- **Deebo Samuel, WR, San Francisco 49ers:** OUT due to a calf injury. With Samuel sidelined, Jauan Jennings will fill the gap alongside Brandon Aiyuk, providing an opportunity for potential offensive explosions.

- **Raheem Mostert, RB, Miami Dolphins:** Doubtful with a chest injury, making way for an expanded role for De'Von Achane and Jeff Wilson Jr.

If you're gearing up for fantasy matchups this week, make sure to keep these updates in mind. Player health and availability can drastically alter the outcomes of games and your fantasy standings. Tune in for the latest news and don't miss out—this week could determine your path to victory! Stay sharp and good luck with your lineups!