Dive into the Depths of Cellular Science!

Get ready to explore the fascinating world of cellular dynamics at the upcoming seminar hosted by the Arkansas Integrative Metabolic Research Center! Join us on Wednesday, September 17, at 10:45 a.m. in BELL 2267 as Brian Cunniff, an esteemed assistant professor in pathology and laboratory medicine, unveils how mitochondrial positioning can dramatically influence gene expression patterns.

Mitochondria: The Powerhouses of Your Cells!

Mitochondria are crucial not just for energy production but also for regulating cell signaling and function. Dr. Cunniff’s research reveals the essential role of Miro1, a protein that tethers mitochondria to microtubule motor proteins, facilitating their proper trafficking within the cell. When Miro1 is knocked out in mouse embryonic fibroblasts, mitochondria become stuck in the perinuclear space. This disruption leads to significant changes in cellular behavior, including slower growth and impaired migration.

Groundbreaking Findings from RNA Sequencing!

What’s more astonishing? Cunniff’s lab has pioneered RNA sequencing experiments influenced by Miro1 expression, identifying genes tied to crucial processes like MAP Kinase signaling, cell proliferation, and migration. The results point to a stark revelation: ERK1/2 phosphorylation—an important signaling event—is markedly elevated in Miro1-deficient cells after serum stimulation. Furthermore, the oxidation status of ERK1/2 in these cells is increased, shedding light on how mitochondrial positioning affects cellular signaling and outcomes.

Dr. Brian Cunniff: A Research Powerhouse!

Dr. Cunniff isn’t just a researcher; he’s a trailblazer in the field. With a Ph.D. from the University of Vermont and postdoctoral training at renowned institutions like Harvard Medical School, he has made significant contributions to understanding mitochondrial dynamics. His lab, supported by both industry and NIH funding, is pioneering a redox-dependent therapy currently making waves in phase 2 clinical trials for malignant mesothelioma.

Join Us for an Eye-Opening Lecture!

Don’t miss your chance to learn from one of the leading voices in mitochondrial research! For more details, contact Kimberley Fuller at [email protected]. Mark your calendars for this enlightening seminar that promises to illuminate the intricate dance of mitochondria and their vital role in cellular health!