Science

Unlocking the Brain: Revolutionary Multiscale Simulations Connect Micro and Macro Activity

2025-07-01

Author: Emily

A Leap in Neuroscience: Bridging the Gap Between Levels of Brain Activity

Understanding how minute molecular changes influence the brain's overall functioning has long been a daunting challenge in the field of neuroscience. Many of the brain's intricate mysteries can only be unraveled by examining its activity across multiple levels simultaneously—a strategy known as the "multi-scale" approach. This complex analysis was once thought impossible.

Groundbreaking Research from Paris Saclay University

Recent advances in digital research tools have paved the way for integrating and connecting data across various scales. Building on this foundation, scientists at Paris Saclay University have innovated a cutting-edge multiscale modeling approach. This groundbreaking method simulates how tiny changes at the molecular level cascade through different tiers of brain organization, ultimately impacting the macroscopic activity of the brain.

How It Works: Connecting the Dots in Brain Functionality

The new simulations intricately link models of single neurons, spiking neural networks, and mean-field models with comprehensive whole-brain network simulations. Remarkably, these computational models can accurately predict how anesthetics influence synaptic receptors and, in turn, lead to observable changes in large-scale brain activity—a crucial finding supported by empirical evidence.

Implications for Drug Design and Treatment of Brain Diseases

This pioneering computational method that connects different spatial scales is particularly significant for developing pharmaceutical interventions for brain disorders. Many drugs operate on a molecular level, yet their effects can significantly alter overall brain states. By enhancing our understanding of these mechanisms, researchers could refine drug design, making treatments more targeted and effective.

Harnessing Technology From the European Human Brain Project

To create this innovative modeling framework, the research team leveraged a variety of advanced digital technologies developed through the European Flagship Human Brain Project, all accessible via the EBRAINS research infrastructure. This collaboration underscores the potential of technological advancement in unlocking the complexities of the human brain.